Radiant floors are wonderful but radiant in a concrete slab is not practical if you don't want to heat the space all the time. The time constant of a hydronic (or electric, or other in-floor system) is so long that you can't turn on the heat and be ready to occupy the space an hour later. It takes H O U R S to get up to temp. If the lady stands much or walks around much then concrete is very tiring and you can't put thick pads or most heavy rugs over a radiant floor without ruining the system response. Radiant floors can be easily made with other than concrete slabs.
I would recommend a floor with much less thermal mass if you want radiant floor heat in a space that is not occupied most of the time.
If you do want slab floors in a space that you don't want to have to heat all the time then consider a radiant ceiling. With a radiant ceiling you can carpet the slab for comfort and the R-value of the carpet is a good thing instead of bad (as it would be with radiant floors.) I have three rooms with radiant ceilings, two are tiled and one heavily carpeted with heavy pad (master bedroom.) The all have significant insulation under the slab so the floors tend to take on the average room temp and aren't chilly. I also have about 1200 or so sq ft of in-floor hydronic heated tiled slab floor. This is my great room and master bath.
I am "INTO" energy conservation so I have programable setback thermostats. These are used to control hot air distribution (back up heat) and the A/C. Separate T'stats are used for the hydronics and have no setback ability as it is useless with radiant slabs in continuously occupied spaces. The only programable radiant heat I have is the shower which turns on in advance to warm the floors and walls prior to our typical showering time. and off again till a few hours ahead of bed time so a evening shower is comfortable. The shower walls are cement backer board covered with tile and backed with batting, pretty low thermal mass compared to a slab and the automatic system turns on the hot water to the shower 3-5 hours in advance. There are aluminum heat sinks to spread the heat from the pex tubing to the tiled wall.
I would be happy to try to answer any specific questions about radiant heating in general or specifically why I think radiant ceilings would be a good thing for a quilting room.
Radiant is terrifically comfortable and needs no ducts and does not have an air handler so it is super quiet and draft free. NO dust is circulated as there are no ducts or fans. The heat is well distributed. Radiant ceilings do warm the floors with their infra red radiation so you should insulate the floors, slab or otherwise.
Radiant ceilings with normal sheetrock have a low thermal mass and begin to make the room comfortable fairly quickly, way faster than heating a slab.
Finally... I don't want to pick a fight with anyone but RADIANT systems heat the air very little. Eventually the air will warm by contact with warm objects like the radiant panel itself (ceiling or floor) and things heated by radiant energy. Air, being virtually transparent to IR, doesn't intercept the radiation and get heated in the process. This is OK as comfort is much more dependent on the radiant environment than the air temp.
Pat