All houses are plumbed different....so its hard to say.
I had an issue with my kitchen drain a few years ago. The kitchen is about 30' away from the main plumbing and the rest of the house and has its own vent stack through the room. The "clog" was at some point after the vent stack. And its a double sink. So after figuring out how to plug the drain I WASNT plunging.....I plunged and plunged to no avail. I had to climb on the roof and plug the vent stack. Still couldnt get it to plunge.
Went to the shop......and believe it or not....NPT pipe unions.....the female half (dont remember the size) will actually thread onto the p-trap. So with a reducer and a tee, with a pressure gauge, valve, and air nipple.....I hooked it up to the compressor and slowly started letting pressure build.....
About 8PSI she finally let go and havent had problems since.
But a word of caution if anyone else wants to try this......put something.....like an old bath towel or something over other drains in the house. Cause I had a helluva mess in the stand up shower in the master bath
But.....even after it was clear......It was another two months before I realized I had the vent on the roof still plugged and never had an issue with draining.
IF your lines are clear......it should never NOT drain due to a vent......the vent is to keep your p-traps full instead of sucking them dry when flushing a toilet