I have had a stainless MKII for a long time and have put 10's of thousands of rounds thru it. Works great, and still does. The wifey has a Ruger 22/45. Which is basicly the same thing, but a polymer lower instead of stainless like mine, and the grip angle approximates a 1911. All of the MK2's Mk3's and 22/45's, are a bit of a pain to take down and reassemble. Actually the take down is not bad, but the re assembly will leave you scratching your head until you have done it a few time. of course now with the MK4's, they have fixed all of that and it is now the easiest 22 target pistol to take down on the market. The old Colt Woodsman, which I dearly loved, is probably the hardest to reassemble. I have to have a book, on the ones I have done. The woodsman has the rear sight on the slide, and of course that moves and may not always be as precise like the Ruger which the front and rear sight are on the same barrel/reciever piece which is fixed, and has a "bolt" that moves inside the receiver.
All that said, all of the big 3 common target pistols the Buckmark, the MK4, and the Victory are all good. If you have the money, get the MK4.. I would buy them in this order...Ruger 1, Victory 2, and Buckmark 3. But each to their own.
