I was involved in a commercial diesel test oil program over 20 years ago. The trucks were GMC Brigadiers with Detroit 6N71 TA's. We had two different grades of dino oils and one grade of synthetic. The trucks w/synthetic leaked oil noticeably more than the ones with the dino, although two stroke Detroits were known for oil leakage. However, in very cold weather the synthetic engines would spin over much faster on the starter than did the others. The trucks were traded at 500k (mileage), so long term effects really weren't known.
A bit later, I started running synthetic in a '90 Saab that had about 40k on it. In one month's time it leaked a quart of oil all over the garage floor, so I went back to dino and the leaking stopped.
I have found Japanese vehicles to be very happy with synthetics (no leakage) and the experience with cold weather starting with the Detroits leads me to believe it's a better cold weather application. These days, I run it in my Tacoma, my wife's CRV, my Gold Wing, and of course the Kubota (the two vehicles go 10k between oil changes). And, as others have said, newer vehicles across the board will most likely be happy with synthetic. Its cold weather starting improvement coupled with the fact that it won't break down at high temps (hot summer days mowing) makes me draw the conclusion that it's a better oil, and if one extends the oil change intervals (which I believe is not harmful) it will be cost effective as well.