I have three mini splits 2 Hyper Heat 9K BTU and 1 12K BTU Mitsubishi that are one of the most efficient units @ 30 SEER, and Daikin and Fujitsu make similar units. We use them for cooling and heating (but have a boiler in the house for colder temps). They provide heat at $1.69 per gallon oil per BTU so very competitive when fuel oil is at $2.69 a gallon here.
The one 9K is installed in my garage/office 1000 SF, the other 9K is in our upstairs 900 SF, and the 12K unit does the whole house downstairs area 30x50 but is in main living area/kitchen/den 30x30.
The downside to window is ac energy cost $.20/KW here, with 3 window ac units the monthly bill in the summer would increase $100/month with the 3 Mini splits $40 for three to four months. Now with the mini splits we heat and cool for a lot less. Also the removal and annual storage of the window ac units was a job and hard on the back.
The upside to window AC is low initial cost, they get the job done, but in the long run are more costly. The downside to Mini splits is upfront cost $3K each includes installation by a contractor, BUT you get a 30% federal tax credit for the entire installation, and another local energy rebate of $500/ton so this reduces the total cost to $1500 net per unit,
If you buy the Mr Cool or similar units, you can get rebates too, it depends on their efficiency ratings and if they qualify, Bottom line, if you need cooling and heating and can DIY, the mini splits are the way to go. If just cooling and short term, a window AC unit is good.