After we bought our land we decided to restore (re-establish) Iowa prairie. To do so we no till planted RR soy beans and then sprayed it with round up to kill all grass and weeds. Since we wanted to place the land in CRP we decided to maintain crop for number of years to qualify. Third year of doing so we got soy seed contaminated with RoundUp resistant pig weed which basically chocked the beans that we hardly broke even. You can google RoundUp resistant weed. There are many articles on internet about the issue.
Farmers Face Tough Choice On Ways To Fight New Strains Of Weeds : The Salt : NPR.
We tried to kill it by discing it twice, mowing etc. Discing "woke up" many other weed seeds laying dormant in the soil. In other words the prairie restoration is a total failure. The weeds are dense enough now that I am hoping we could burn it next spring and see what will happen. But seems to me that deer, turkeys, quails and pheasants don't mind it because they congregate on the land in higher numbers than before.