SouthernX,
I have a 2008 F-550 with the 6.4L engine and 4.88 rear end. I only have 5,200 miles on the truck but have not had any issues to date. The truck averages between 7 and 8 mpg. Last week I pulled a 32' trailer (GVW was around 37,000#) for 250 miles on the highway. I checked my mileage when I got home and only got 6 mpgI went through both fuel tanks on the trip home.
Hope this helps.
Your experience is exactly in line with what others I've spoken to have gotten. They didn't have any issues with the truck between fuel stops, but make a LOT of fuel stops!
There is no comparison between a 250 and 550 for fuel economy - they just don't relate to each others. It's Apples to water melons.