While I've never happened to use Motorcraft oils, my impression is that they supply a solid (good quality) oil. I'd have no issue using spec Motorcraft oil in your truck.
Had to look back a bit, wasn't sure what engine you have - looks like 5.4L. On a turbo application, I'd lean towards a full synthetic for general use, but I suspect a Motorcraft semi-synthetic would have no trouble meeting spec on your 5.4. 94 touched on filters, can't go wrong with Motorcraft there.
I change my (old) vehicles here on Severe Service schedules. The issue with doing that manually is that many people paid no attention to those written Severe Service specs. With computerized OCI, I probably wouldn't take it below 20%, w/o doing my own oil analysis.
Don't know what year yours is; if your climate is like ours re. salt damage, another thing that can cause strange driveability issues is the variable speed fuel pump mounted on the rear axle of certain F150s years. Outright failure is easy to diagnose, but some don't fail cleanly (meaning 100% dead) - if common in your area, then your shop would be familiar with this problem.
Rgds, D.