The old rule was R19 is used on 5.5" material (2x6), R11 on typical 3.5" (2x4). I guess the insulation guys have figured out how to increase the R value on each (R21/R13) With a true 2x4 I guess R15 might work. You haven't mentioned your heating supply yet.
Probably a rinnai, although would love to find a wood burning solution.