My wife drives an '08 Accrod V6, which was my car until we traded in her Pilot on my '10 F-150. Car has about 50K on it now. I will agree with comments that it has a lot of road noise, especially compared to my F-150, but of course you're riding a lot closer to the road in any sedan vs pickup. I don't agree that it's boring to drive, especially with the V6, which is peppy when you step on it. I find it rather sporty to drive, and the original Michellins are holding up well. I will say that we could never get the Honda dealer to properly balance the tires but getting a road force balance at my Ford dealer fixed that and it's never driven as well as it does now. One minor issue is that the plastic seat base trim on the driver's side popped loose and would require a complete seat removal to put it back together, so I'm gonna try gluing it first, and if that doesn't work, maybe a trim head screw inconspicuously placed may be in order.
I think '08 was the first year Honda put variable cylinder mgt on the V6's, so it runs on either 3 or 4 cylinders when possible, which is usually highway driving. I have mixed opinions on it. I do like the added milage you get when highway cruising - did 30 mpg on a long trip back from NC. But, I find that without the cruise on, I have to concentrate on holding a steady speed, otherwise it tends to drop MPH if you're not constantly re-adjusting pedal position manually. This is more of an issue when driving hillier terrain and at speeds under about 65 mph. If you can run the car at 75 mph or higher, it holds speed much better with the VCM kicking in and out. Now, the real issues is that about 2 years ago when the car had around 30K on it, the check engine light came on when my wife was coming home from shopping. She said the car ran real rough and wouldn't make any power (but of course she drove it home anyway). Since it was under warranty, I had it flatbedded to the dealer. The diagnoses was fouled plugs on 2 of the cylinders and a needed computer update. After experiencing this issue, seems there are quite a few similar issues posted on line by other V6 owners.
To boot, the car has always used some oil between changes, which we do every 5k. It will use about 1-1.5 quarts between oil changes, which of course the dealer says is within spec. I am watching to see if it gets any worse. This is the first new car we've owned that uses oil. Have had 4-5 Toyotas, a Honda Pilot and several Subaru's that never used oil. My F-150 seems fine so far. I still like the car overall and if the oil consumption doesn't get any worse and we don't have any more fouled plug issues, I'd be keeping it for as long as possible, but we'll see.