This thread is why it is so awesome to be here in America! There are so many incredible places to live. In many ways I envy the thought of being able to just pull up stakes and start over somewhere else. If I could pick anywhere, it would probably be somewhere in Texas, I figure then I might make it to 6' tall instead of stalling out at 5'10". I've lived at the foot of the Rockies in Longmont, CO. Amazing country, but it'll cost you. Had a job offer in the Carolina's - lots of lakes and warmth for summer boating, still have the mountains and an ocean close enough for a weekend getaway.
But, I'm settled in KY where my family has been for many generations. I can look across the fence on the back of my farm and see the house my great great grandfather built, drive a mile down the road and see the general store my great grandmother ran, the farm my papaw still runs, the house my dad grew up in... my roots are way too deep to pull up. I do love it here as well. Centrally located for the eastern states. Can be in NY or Texas in a day's drive (that's either, not both!). Can be at the beach in one of several states (NC, SC, FL, AL...) or at Lake Michigan in an afternoon. We have 4 distinct seasons, which I love. About the time you get sick of the heat, the leaves start changing, nice jacket weather, then winter sets in and you get some snow - nothing crazy, but enough to enjoy. About the time your sick of being cold everything thaws out and you get lush green pastures, flowers, trees...and soon you are ready to head back to the lake. Yep, it's humid in the summer, and we have pleanty of bugs, but there are ways to deal with it. We can be a bit backwards compared to the rest of the country, but I kind of like that too, keeps the population and land prices reasonable. We have state income tax AND a 6% sales tax, but cost of living is decent.
There's no one place that's best to live, but what you either have there or take with you will make it so. If you have the means, buy/rent an RV and go check some places out. Spend a few months, see what you like. Good luck.