What kind of snakes are you guys shooting that need more "stopping power" than a .22 can deliver? The comment about a .38/.357 shotshell backed up by hollow points just made me crack up.
Now, I realize that the higher caliber shotshell will carry more shot, thus making a better chance of a lethal first shot, and the same with 12 ga/410 shotgun, because then you don't have to be as accurate when dealing with you legless adversary. But the idea of needing to use a .357 hollowpoint or a .45 acp to kill a snake.....if it takes that kill a snake, it's gonna have to bite me in the backside, 'cause I'm running away.
I also realize that carrying a larger caliber is advantageous in case you need the firearm for dealing with a coyote/cougar/bobcat/felon/feral pig/terrorist/Rainbow Vacuum Salesman/skunk/opossum/etc., so I certainly respect that option. In that view, the revolver with shot followed by hollowpoints makes alot more sense.
And I also agree with a previous poster - I haven't shot (at) a snake in years - I usually just kill them with shovel/hoe/stick/rock/etc., including the copperheads that I found at the pond in the summer.
Good luck and take care.