No sir you do not use, you never use, nor ever use a kerosene, propane or fuel oil fired heater in an enclosed garage or garages of any size without all the doors open in any circumstance what so ever as their is no separaton of Carbon Monoxide fumes from combustion.
The white gas and propane radiant heaters are also a no no with doors closed in any circumstance.
Adding a box fan blowing in fresh air in front of the garage door on the floor aids in removing the Carbon monoxide and continually adds fresh air into the open garage space diluting the fumes.