I think just about everything has been covered (that it's mostly a non-issue at low speeds) but one thing about having a smaller 'air pocket' due to tire fill is that it also affects the pressure rise, or 'rate of gain', when you hit things. Basically, if the whole tire is full of air and you bump into something hard the pressure might spike from 20 to 25, just as an example. If you fill most of the tire and have a smaller air pocket, that same impact might spike pressure from 20 to 50, making the tire feel a lot stiffer. Air acts like a 'progressive rate spring' and the smaller the air volume, the quicker the progression. I dont think it's a factor for most people but technically speaking if you are buying radials partially for ride quality, then yes, filling it 75% with noncompressible liquid leaving only 25% air is going to make the tire feel stiffer, giving away some indeterminate amount of the ride quality gain.