If it is hydraulic, I use Loctite 545. If it is water, I use Rectorseal #5. If it is gas, I use gas rated Teflon tape and sometimes Rectorseal as well. Never had any of these leak if the fitting is properly tightened.
The fitting could be too tight or too loose, it will leak either way. I always get them just about as tight as possible, but it is possible to over tighten. Also these days some fittings are poor quality and might not seal at all. I got some of those one time at a big box store.